Amniotic  fluid  analysis  for  monogenic    disorders involves testing fetal DNA in the amniotic     fluid   to detect single-gene genetic conditions.  The process begins   with   amniocentesis,  where  a   sample   of amniotic  fluid  is  collected  during  pregnancy.  The fetal DNA extracted from  the  fluid  is  analyzed  for mutations   or   abnormalities    in    specific    genes responsible for inherited   conditions.   This   test   is typically used when there is a known family   history of monogenic disorders, such as cystic   fibrosis   or sickle cell anemia. It provides a definitive  diagnosis of whether the fetus  carries  or  is  affected  by  the disorder. The procedure is  usually  performed  after the  15th   week   of   pregnancy.    Although    highly accurate, it carries a small  risk  of  miscarriage  due to the invasive nature of the test.