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Y-Chromosome Microdeletions
(YCM)

Y-chromosome microdeletions    (YCM)   are   small, deletions of genetic material on the Y  chromosome, often    affecting    regions    important     for   sperm production and male fertility.  These   deletions   are typically associated with male infertility, particularly in men  with   low   sperm   count   or    azoospermia (absence of sperm).   YCM   are    most    commonly found   in     three     specific     regions     of    the  Y chromosome:   AZFa,    AZFb,   and   AZFc.   Genetic testing, such    as     Y-chromosome    microdeletion testing, can help diagnose these    deletions  in men experiencing infertility.   The   presence    of    these deletions    can    affect    the    choice    of    fertility treatments, such as sperm    retrieval    or    assisted reproductive technologies.   YCM   is    inherited in a paternal      pattern,   meaning   fathers   with   these deletions can pass them  on   to   their   sons.   Early detection     can   aid    in    providing      appropriate counseling and   treatment   options   for      affected individuals.

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